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Lancet Oncology, Artikel i vetenskaplig tidskrift Artikel i vetenskaplig tidskrift Direkt till fulltext på webbsida. Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease CAD. Pulmonary IL-1β expression in early life causes permanent changes in lung structure and function in adulthood. Atrial fibrillation AF is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. Göran Wennergren Acta paediatrica, Artikel i vetenskaplig tidskrift Artikel i vetenskaplig tidskrift Direkt till fulltext på webbsida. However, adding metabolites to an existing risk score improved model fit only marginally.

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Independent genetic instruments for expression of SREBF1 supported the findings linking methylation to adiposity and cardiometabolic disease.

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Andersson Plos One, Artikel i vetenskaplig tidskrift Artikel i vetenskaplig tidskrift Direkt till fulltext på webbsida. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs as driving T2D association. However, the cross-sectional nature of the data limits definitive causal determination. Parental age and risk of genetic syndromes predisposing to nervous system tumors: Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways. Pediatric diabetes, Artikel i vetenskaplig tidskrift Artikel i vetenskaplig tidskrift Direkt till fulltext på webbsida.

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